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Sotorasib
  • Synonyms: AMG510
  • ATC: L01XX73
  • Use: Lorem 
  • Chemical name: Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam
  • Formula: Lorem ipsum dolor sit amet,
  • MW:560.6 g/mol
  • CAS-RN:2252403-56-6
  • InChI Key:NXQKSXLFSAEQCZ-SFHVURJKSA-N
  • InChI:InChI=1S/C30H30F2N6O3/c1-​6-​23(40)​36-​12-​13-​37(18(5)​15-​36)​28-​19-​14-​21(32)​26(24-​20(31)​8-​7-​9-​22(24)​39)​34-​29(19)​38(30(41)​35-​28)​27-​17(4)​10-​11-​33-​25(27)​16(2)​3/h6-​11,​14,​16,​18,​39H,​1,​12-​13,​15H2,​2-​5H3/t18-​/m0/s1

Substance Classes

Synthesis Path












Substances Referenced in Synthesis Path

CAS-RN Formula Chemical Name CAS Index Name
82671-06-5 C6H2Cl2FNO2 2,6-dichloro-5-fluoro-nicotinic acid
113237-20-0 C6H3Cl2FN2O 2,6-dichloro-5-fluoro-nicotinamide
1698293-93-4 C9H14N2 2-isopropyl-4-methyl-pyridin-3-amine
2252403-81-7 C16H15Cl2FN4O2 2,6-dichloro-5-fluoro-N-(2-isopropyl-4-methylpyridin-3-yl)carbamoyl nicotinamide
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem
Lorem Lorem Lorem Lorem

Trade Names

Country Trade Name Vendor Annotation
USA Lorem Lorem
(wfm = withdrawn from market)

Formulations

  • Loremipsumdolorsit

References

    • Hong, D. S. et al., N. Engl. J. Med., (2020) 383, 1207-1217.
    • a) Lanman, B. A. et al., J. Med. Chem., (2021) 63 (1), 52-65.
    • US 99 999 999 (Amgen; 31.12.2019; appl. 21.5.2018; USA-prior. 22.9.2017).
    • ab) Pawas, L. et al., Tetrahedron, (2019) 75(32), 4866-4870.
    • WO 9999 999999 (Amgen; 20.5.2021; appl. 13.11.2020; USA-prior. 14.11.2019).
    • ac) WO 9999 999999 (Amgen; 22.8.2020; appl. 15.11.2019; USA-prior. 16.11.2018).
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